2nd University in Ghana according to the International Tertiary Rankings

Rank in Ghana=2 
World Rank=1874 
Kwame Nkrumah University of Science & Technology

Kwame Nkrumah University of Science and Technology is a University in Kumasi, Ghana. It is the second public university established in the country as well as the second largest University in Ghana. The University has its roots in the plans of the Asantehene Agyeman Prempeh I to establish a University in Kumasi as part of his drive towards modernization of his kingdom. This plan never came to fruition due to the clash between British empire expansion and the desire for King Prempeh I to preserve his kingdom's independence.

However, his younger brother and successor, King Agyeman Prempeh II, upon ascending to the Golden Stool in 1935, continued with this vision. Events in the Gold Coast in the 1940s played into his hands. First there was the establishment of the University College of the Gold Coast. Second there were the 1948 riots and the consequent Watson Commission report which recommended that a university of sciences be established in Kumasi. Thus, in 1949, the dream of the Prempehs became a reality when building started on what was to be called the Kumasi College of Technology.
Source| Wikipedia